西班牙成年吸烟者与非吸烟者外周血淋巴细胞中的姐妹染色单体交换（SCE）、高频细胞（HFCs）及SCE分布模式。

Sister chromatid exchange, (SCE), High-Frequency Cells (HFCs) and SCE distribution patterns in peripheral blood lymphocytes of Spanish adult smokers compared to non-smokers.

作者信息

Sebastià Natividad, Hervás David, Almonacid Miguel, Villaescusa Juan Ignacio, Soriano José Miguel, Sahuquillo Vicenta, Esteban Valentín, Barquinero Joan Francesc, Verdú Gumersindo, Cervera José, Such Esperanza, Montoro Alegría

机构信息

Department de Medicina Preventiva i Salut Pública, Facultat de Farmàcia, Universitat de Valencia, Burjassot, Spain.

Unidad de Bioestadística IIS La Fe, Instituto de Investigación Sanitaria La Fe, Valencia, Spain.

出版信息

Food Chem Toxicol. 2014 Apr;66:107-12. doi: 10.1016/j.fct.2014.01.011. Epub 2014 Jan 18.

DOI:10.1016/j.fct.2014.01.011

PMID:24444548

Abstract

According to the International Agency for Research on Cancer, smoking tobacco is a major cause of cancer in humans. It causes about half of all male cancer deaths and an ever increasing number of cancer deaths in females. The aim of this study was to establish whether cigarette smoking increases sister chromatid exchanges (SCEs) in peripheral blood lymphocytes in two Spanish population groups; light and heavy smokers. The mean number of High-Frequency Cells (HFCs) was determined and, the SCE distribution pattern among the chromosomes was analysed represented by a ratio described below. A local sample of 101 adult smokers (n=48) and non-smokers (n=53), aged from 18 to 49 years, was studied using SCE levels in peripheral lymphocytes. Heavy smoking (≥ 10 cigarettes per day) increased significantly the SCE frequency and the HFC parameters. Neither age nor sex significantly influenced the frequencies in the groups studied.

摘要

根据国际癌症研究机构的研究，吸烟是导致人类患癌症的主要原因。它导致了约一半的男性癌症死亡病例，并且在女性中导致的癌症死亡病例数量也在不断增加。本研究的目的是确定吸烟是否会增加两个西班牙人群组（轻度吸烟者和重度吸烟者）外周血淋巴细胞中的姐妹染色单体交换（SCE）。测定了高频细胞（HFC）的平均数量，并分析了染色体间SCE的分布模式，该模式由以下所述的比率表示。使用外周淋巴细胞中的SCE水平对101名年龄在18至49岁之间的成年吸烟者（n = 48）和非吸烟者（n = 53）的本地样本进行了研究。重度吸烟（每天≥10支香烟）显著增加了SCE频率和HFC参数。年龄和性别对所研究的组中的频率均无显著影响。