Niidome T, Kim M S, Friedrich T, Mori Y
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Japan.
FEBS Lett. 1992 Aug 10;308(1):7-13. doi: 10.1016/0014-5793(92)81038-n.
The complete amino acid sequence of a novel calcium channel (designated BII) from rabbit brain has been deduced by cloning and sequencing the cDNA. The BII calcium channel is structurally more closely related to the BI calcium channel than to the cardiac and skeletal muscle L-type calcium channels. Blot hybridization analysis of RNA from different tissues and from different regions of the brain shows that the BII calcium channel is distributed predominantly in the brain, being abundant in the cerebral cortex, hippocampus and corpus striatum.
通过对兔脑新钙通道（命名为BII）的cDNA进行克隆和测序，已推导其完整氨基酸序列。BII钙通道在结构上与BI钙通道的关系比与心肌和骨骼肌L型钙通道的关系更为密切。对来自不同组织和脑不同区域的RNA进行印迹杂交分析表明，BII钙通道主要分布在脑中，在大脑皮质、海马体和纹状体中含量丰富。
