Mi C
Department of Pathology, Chongqing University of Medical Sciences.
Zhonghua Bing Li Xue Za Zhi. 1992 Apr;21(2):106-8.
Altogether 20 chordomas were reported. The site distribution included 9 cases at the sacrococcygeal region, another 9 cases at the spheno-occipital region, 1 at the cervical vertebra, and another 1 at the lumbar vertebra. Histologic examination revealed that characteristic "physaliphorous cells" were easily identified in all the 19 cases. Tissue for immunohistochemistry study was available in 18 cases. Among them, tumor cells were found strongly positive to EMA, but negative for CEA. 16/18 cases also showed positive for keratin and S-100 protein. Totally, 2 cases were studied ultrastructurally and there were abundant RER and microfilaments seen in the cytoplasm of the tumor cells but only few surface microvilli detected. The epithelial nature of chordoma is strongly supported by the ultrastructural and immunohistochemical findings of these 20 cases.
共报告了20例脊索瘤。部位分布包括：骶尾部9例，蝶枕部9例，颈椎1例，腰椎1例。组织学检查显示，在所有19例中均易于识别出特征性的“空泡细胞”。18例有用于免疫组织化学研究的组织。其中，肿瘤细胞对EMA呈强阳性，但对CEA呈阴性。16/18例对角蛋白和S-100蛋白也呈阳性。总共对2例进行了超微结构研究，在肿瘤细胞的细胞质中可见丰富的粗面内质网和微丝，但仅检测到少量表面微绒毛。这20例的超微结构和免疫组织化学结果有力地支持了脊索瘤的上皮性质。
