BLASCHKO H, CHRUSCIEL T L
Br J Pharmacol Chemother. 1959 Sep;14(3):364-7. doi: 10.1111/j.1476-5381.1959.tb00258.x.
A number of compounds have been tested as substrates of, first, the amine oxidases of rabbit and guinea-pig liver and of goat, pig, horse, and dog plasma and, second, the "diamine oxidase" of pig kidney. Of the three xylylenediamines [di(aminomethyl)benzenes]tested, m-xylylenediamine was found to be a substrate of the liver oxidase. All the plasma oxidases tested acted on both m- and o-xylylenediamine. Both 3- and 4-picolylamine (3- and 4-aminomethylpyridine) were readily oxidized by the liver enzymes; all the plasma oxidases tested oxidized 2-, 3-, and 4-picolylamine. 4-Picolylamine was more rapidly oxidized by horse and dog plasma than any other substrate hitherto examined.
已经对多种化合物作为底物进行了测试，首先是兔和豚鼠肝脏以及山羊、猪、马和狗血浆中的胺氧化酶的底物，其次是猪肾脏中的“二胺氧化酶”的底物。在所测试的三种二甲苯二胺[二（氨基甲基）苯]中，间二甲苯二胺被发现是肝脏氧化酶的底物。所有测试的血浆氧化酶都作用于间二甲苯二胺和邻二甲苯二胺。3-和4-吡啶甲胺（3-和4-氨基甲基吡啶）很容易被肝脏酶氧化；所有测试的血浆氧化酶都能氧化2-、3-和4-吡啶甲胺。马和狗的血浆氧化4-吡啶甲胺的速度比迄今为止检测的任何其他底物都要快。
