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The mitochondrial megachannel is the permeability transition pore.

作者信息

Szabó I, Zoratti M

机构信息

Consiglio Nazionale delle Ricerche, Istituto di Patologia Generale, Padova, Italy.

出版信息

J Bioenerg Biomembr. 1992 Feb;24(1):111-7. doi: 10.1007/BF00769537.

DOI:10.1007/BF00769537
PMID:1380498
Abstract

Single-channel electrophysiological recordings from rat liver mitoplast membranes showed that the 1.3-nS mitochondrial megachannel was activated by Ca++ and inhibited by Mg++, Cyclosporin A, and ADP, probably acting at matrix-side sites. These agents are known to modulate the so-called mitochondrial permeability transition pore (Gunter, T. E., and Pfeiffer, D. R. (1990) Am. J. Physiol. 258, C755-C786) in the same manner. Furthermore, the megachannel is unselective, and the minimum pore size calculated from its conductance is in agreement with independent estimates of the minimum size of the permeabilization pore. The results support the tentative identification of the megachannel with the pore believed to be involved in the permeabilization process.

摘要

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本文引用的文献

1
Adenine nucleotide transport during cardiac ischemia.心脏缺血期间的腺嘌呤核苷酸转运
Am J Physiol. 1981 Nov;241(5):H663-71. doi: 10.1152/ajpheart.1981.241.5.H663.
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Mitochondrial calcium transport.线粒体钙转运
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Intramitochondrial adenine nucleotides and energy-linked functions of heart mitochondria.线粒体内腺嘌呤核苷酸与心脏线粒体的能量相关功能。
硫化物醌氧化还原酶有助于线粒体通透性转换孔的电压感应。
FASEB J. 2024 Feb 29;38(4):e23494. doi: 10.1096/fj.202301280R.
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Mitochondrial F-ATP Synthase Co-Migrating Proteins and Ca-Dependent Formation of Large Channels.线粒体F-ATP合酶共迁移蛋白与大通道的钙依赖性形成
Cells. 2023 Oct 7;12(19):2414. doi: 10.3390/cells12192414.
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Investigation of Properties of the Mitochondrial Permeability Transition Pore Using Whole-Mitoplast Patch-Clamp Technique.采用全线粒体膜片钳技术研究线粒体通透性转换孔的性质。
DNA Cell Biol. 2023 Aug;42(8):481-487. doi: 10.1089/dna.2023.0171. Epub 2023 Jun 13.
6
Revealing the single-channel characteristics of OprD (OccAB1) porins from hospital strains of Acinetobacter baumannii.揭示鲍曼不动杆菌医院株 OprD（OccAB1）孔蛋白的单通道特性。
Eur Biophys J. 2023 Apr;52(3):131-143. doi: 10.1007/s00249-023-01651-2. Epub 2023 Apr 13.
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ATP synthase FF structure, function, and structure-based drug design.ATP 合酶 FF 的结构、功能及基于结构的药物设计。
Cell Mol Life Sci. 2022 Mar 6;79(3):179. doi: 10.1007/s00018-022-04153-0.
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Methods of Measuring Mitochondrial Potassium Channels: A Critical Assessment.测量线粒体钾通道的方法：批判性评估。
Int J Mol Sci. 2022 Jan 21;23(3):1210. doi: 10.3390/ijms23031210.
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Molecular mechanisms and consequences of mitochondrial permeability transition.线粒体通透性转换的分子机制及其后果。
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Modulation and Pharmacology of the Mitochondrial Permeability Transition: A Journey from F-ATP Synthase to ANT.线粒体通透性转换的调节和药理学：从 F-ATP 合酶到 ANT 的旅程。
Molecules. 2021 Oct 26;26(21):6463. doi: 10.3390/molecules26216463.
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4
Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides.核苷酸对线粒体内膜Ca2+激活的亲水性通道的变构抑制作用。
J Membr Biol. 1980 Jun 15;54(3):231-6. doi: 10.1007/BF01870239.
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The equivalent pore radius of intact and damaged mitochondria and the mechanism of active shrinkage.
Biochim Biophys Acta. 1972;283(1):23-9. doi: 10.1016/0005-2728(72)90094-1.
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Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.环孢菌素A对无机磷酸盐和氧化应激激活的心脏线粒体中钙依赖性孔道的抑制作用。
Biochem J. 1988 Oct 1;255(1):357-60.
7
Action of cyclosporine on mitochondrial calcium fluxes.环孢素对线粒体钙通量的作用。
J Bioenerg Biomembr. 1987 Jun;19(3):297-303. doi: 10.1007/BF00762419.
8
The inner mitochondrial membrane contains ion-conducting channels similar to those found in bacteria.线粒体内膜含有与细菌中发现的类似的离子传导通道。
FEBS Lett. 1989 Dec 18;259(1):137-43. doi: 10.1016/0014-5793(89)81513-3.
9
Mitochondrial channel activity studied by patch-clamping mitoplasts.通过膜片钳技术研究线粒体膜的通道活性。
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10
Further investigation on the high-conductance ion channel of the inner membrane of mitochondria.线粒体内膜高传导性离子通道的进一步研究。
J Bioenerg Biomembr. 1989 Aug;21(4):485-96. doi: 10.1007/BF00762520.