Tromm A, Hüppe D, Thau I, Schwegler U, Kuntz H D, Krieg M, May B
Bergmannsheil Bochum, Universitätsklinik, Abteilung für Gastroenterologie und Hepatologie, Bundesrepublik, Deutschland.
Z Gastroenterol. 1992 Jul;30(7):449-53.
Significantly decreased levels of serumcholinesterase (CHE) were found in acute Crohn's disease (= CD) (3.2 +/- 1.0 KU/L) and acute ulcerative colitis (= UC) (3.54 +/- 1.6 KU/L) as compared to patients with mild or quiescient disease (CD: 5.5 +/- 1.1 KU/L; UC: 5.59 +/- 0.94 KU/L) and healthy controls (5.69 +/- 1.3 KU/L). Suppression of CHE was most evident in Crohn's colitis (2.98 +/- 1.0 KU/L) and extensive UC (2.96 +/- 1.28 KU/L). Intraindividual comparison showed an increase of CHE-levels during treatment with steroids and salicylates. There was no significant correlation to the reduced bodyweight-levels in severe IBD. Best correlations were seen between CHE/albumin (CD: r = +0.61; UC: r = +0.73) and CHE/hematocrit (CD: r = +0.50; UC: r = +0.61) in severe inflammatory bowel disease. The results of a discriminant analysis showed that CHE-levels can predict the degree of activity correctly in the majority of patients with CD and UC. It is suggested that the decrease of serumcholinesterase reflects an inhibition of liver synthesis as an acute phase response-induced by endotoxins and cytokines.
与轻度或静止期疾病患者（克罗恩病：5.5±1.1KU/L；溃疡性结肠炎：5.59±0.94KU/L）及健康对照者（5.69±1.3KU/L）相比，急性克罗恩病（CD）患者（3.2±1.0KU/L）和急性溃疡性结肠炎（UC）患者（3.54±1.6KU/L）的血清胆碱酯酶（CHE）水平显著降低。CHE抑制在克罗恩结肠炎（2.98±1.0KU/L）和广泛性UC（2.96±1.28KU/L）中最为明显。个体内比较显示，在使用类固醇和水杨酸盐治疗期间CHE水平升高。严重炎症性肠病患者体重减轻水平与之无显著相关性。在严重炎症性肠病中，CHE/白蛋白（CD：r=+0.61；UC：r=+0.73）和CHE/血细胞比容（CD：r=+0.50；UC：r=+0.61）之间的相关性最佳。判别分析结果表明，CHE水平可在大多数CD和UC患者中正确预测疾病活动程度。提示血清胆碱酯酶降低反映了内毒素和细胞因子诱导的急性期反应导致肝脏合成受到抑制。
