Elmquist J K, Fox C A, Ross L R, Jacobson C D
Department of Veterinary Anatomy, Iowa State University, Ames 50011.
Brain Res Dev Brain Res. 1992 Jun 19;67(2):161-79. doi: 10.1016/0165-3806(92)90217-k.
The distribution of galanin-like immunoreactivity has been characterized in the brain of the adult and developing Brazilian opossum (Monodelphis domestica). Two commercially available antisera were used to examine the distribution of galanin-like immunoreactive (GAL-IR) cells and fibers. Nuclear groups containing GAL-IR cell bodies and fibers were seen throughout the adult opossum brain. The distribution of GAL-IR elements seen is similar to that reported for other mammals. Based on these findings, we believe that galanin may have similar physiological functions in the adult Brazilian opossum as has been reported for other mammals. In the developing brain, GAL-IR structures were seen as early as 1 day postnatal (PN) in the developing hypothalamus and brainstem. By days 5 and 10 PN, there was a robust expression of galanin-like immunoreactivity in specific regions of the brain. Since neurogenesis and brain morphogenesis are actively occuring postnatally in the opossum, galanin may be playing a role in the differentation of specific regions of the brain.
已对成年和发育中的巴西负鼠（Monodelphis domestica）大脑中甘丙肽样免疫反应性的分布进行了表征。使用两种市售抗血清来检查甘丙肽样免疫反应性（GAL-IR）细胞和纤维的分布。在成年负鼠的整个大脑中都可见到含有GAL-IR细胞体和纤维的核团。所观察到的GAL-IR成分的分布与其他哺乳动物的报道相似。基于这些发现，我们认为甘丙肽在成年巴西负鼠中可能具有与其他哺乳动物报道的类似生理功能。在发育中的大脑中，早在出生后1天（PN），在下丘脑和脑干的发育过程中就可见到GAL-IR结构。到出生后第5天和第10天，大脑的特定区域有强烈的甘丙肽样免疫反应性表达。由于负鼠出生后神经发生和脑形态发生活跃，甘丙肽可能在大脑特定区域的分化中发挥作用。
