Sheth A R, Garde S V, Mehta M K, Shah M G
Institute for Research in Reproduction (ICMR), Bombay, India.
Indian J Exp Biol. 1992 Mar;30(3):157-61.
Hormonal modulation of in vitro biosynthesis of three prostatic secretory proteins, prostate specific acid phosphatase (PSAP), prostate specific antigen (PSA) and prostatic inhibin peptide (PIP) by human benign hyperplasia (BPH) tissue was studied. LH and inhibins caused increase in the synthesis of all three proteins whereas FSH enhanced the synthesis of PIP and PSA only but decreased PSAP synthesis. Prolactin and thyroid releasing hormone decreased synthesis of PIP and PSAP. However, PSA synthesis was enhanced by TRH and was decreased by prolactin. Estradiol caused significant increase in PSA and PSAP but no discernible changes in PIP synthesis were noticed. Testosterone caused an increase in PIP, PSA and PSAP. These data indicate that biosynthesis of PIP, PSA and PSAP by BPH tissue is under multihormonal regulation.
研究了人良性前列腺增生（BPH）组织对三种前列腺分泌蛋白，即前列腺特异性酸性磷酸酶（PSAP）、前列腺特异性抗原（PSA）和前列腺抑制素肽（PIP）体外生物合成的激素调节作用。促黄体生成素（LH）和抑制素可使这三种蛋白的合成增加，而促卵泡生成素（FSH）仅增强PIP和PSA的合成，但降低PSAP的合成。催乳素和促甲状腺激素释放激素降低PIP和PSAP的合成。然而，促甲状腺激素释放激素增强PSA的合成，而催乳素则降低其合成。雌二醇使PSA和PSAP显著增加，但未观察到PIP合成有明显变化。睾酮使PIP、PSA和PSAP增加。这些数据表明，BPH组织中PIP、PSA和PSAP的生物合成受多种激素调节。
