Mohácsi A, Fülöp T, Kozlovszky B, Hauck M, Kiss I, Leövey A
Department of Internal Medicine, University Medical School of Debrecen, Hungary.
J Gerontol. 1992 Sep;47(5):B154-8. doi: 10.1093/geronj/47.5.b154.
Serum and granulocyte elastase-type protease activities were determined simultaneously with their main plasma proteinase inhibitors such as alpha-1-antitrypsin and alpha-2-macroglobulin in healthy control and atherosclerotic (ATS) subjects. The age-related associations of these parameters were also investigated. Serum elastase-type protease activity increased, but not statistically significantly, with aging in both control and ATS subjects. The enhancement of elastase-type protease activity in sera of ATS patients was significantly (p less than .02) greater than control subjects only in the case of the elderly. The granulocytes' elastase activity was significantly greater in granulocytes derived from both middle-aged and elderly ATS patients (p less than .03 and p less than .06) compared to age-matched control subjects. Alpha-1-antitrypsin was not significantly lower, whereas alpha-2-macroglobulin was significantly lower in sera of ATS subjects compared to age-matched control subjects (p less than .01). The conclusion is that increased elastase-type activity and decreased antiproteinase activity should be considered as potential factors in atherosclerotic arterial wall damage. The similarity of the results in the elderly and the ATS subjects suggest that atherosclerosis is an early aging process.
在健康对照者和动脉粥样硬化（ATS）患者中，同时测定了血清和粒细胞弹性蛋白酶型蛋白酶活性及其主要血浆蛋白酶抑制剂，如α-1-抗胰蛋白酶和α-2-巨球蛋白。还研究了这些参数与年龄的相关性。在对照者和ATS患者中，血清弹性蛋白酶型蛋白酶活性均随年龄增长而增加，但无统计学显著差异。仅在老年人中，ATS患者血清中弹性蛋白酶型蛋白酶活性的增强显著（p<0.02）高于对照者。与年龄匹配的对照者相比，中年和老年ATS患者来源的粒细胞中弹性蛋白酶活性显著更高（p<0.03和p<0.06）。与年龄匹配的对照者相比，ATS患者血清中的α-1-抗胰蛋白酶无显著降低，而α-2-巨球蛋白显著降低（p<0.01）。结论是，弹性蛋白酶型活性增加和抗蛋白酶活性降低应被视为动脉粥样硬化动脉壁损伤的潜在因素。老年人和ATS患者结果的相似性表明动脉粥样硬化是一个早期衰老过程。
