Counts D R, Gwirtsman H, Carlsson L M, Lesem M, Cutler G B
Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.
J Clin Endocrinol Metab. 1992 Sep;75(3):762-7. doi: 10.1210/jcem.75.3.1381372.
We studied the relationship of serum insulin-like growth factor-I (IGF-I), IGF-II, the IGF-binding proteins IGFBP-1, IGFBP-2, and IGFBP-3, and GH-binding protein (GHBP; which is postulated to be derived from the extracellular portion of the GH receptor) in normal volunteers and patients with anorexia nervosa before and after a refeeding program. Serum GHBP, IGF-I, and IGFBP-3 were all significantly decreased in low weight patients with anorexia nervosa and returned to nearly normal levels with refeeding. Fasting serum GH and serum IGFBP-1 and IGFBP-2 were significantly increased in low weight patients with anorexia nervosa and also returned to nearly normal levels with refeeding. Serum IGF-II was 27% lower in the low weight group than in normal subjects, but this difference was not statistically significant. Both serum IGF-I and IGF-II were positively correlated with serum IGFBP-3 and negatively correlated with serum IGFBP-1 and IGFBP-2. These data are consistent with the hypothesis that nutritional deprivation alters the GH-IGF axis by down-regulation of the GH receptor or its postreceptor mechanisms, and that this effect is reversible with refeeding.
我们研究了正常志愿者以及神经性厌食症患者在重新进食计划前后血清胰岛素样生长因子-I（IGF-I）、IGF-II、IGF结合蛋白IGFBP-1、IGFBP-2和IGFBP-3，以及生长激素结合蛋白（GHBP；据推测它源自生长激素受体的细胞外部分）之间的关系。神经性厌食症低体重患者的血清GHBP、IGF-I和IGFBP-3均显著降低，重新进食后恢复至接近正常水平。神经性厌食症低体重患者的空腹血清生长激素以及血清IGFBP-1和IGFBP-2显著升高，重新进食后也恢复至接近正常水平。低体重组的血清IGF-II比正常受试者低27%，但这种差异无统计学意义。血清IGF-I和IGF-II均与血清IGFBP-3呈正相关，与血清IGFBP-1和IGFBP-2呈负相关。这些数据与以下假设一致，即营养剥夺通过生长激素受体或其受体后机制的下调改变生长激素-IGF轴，且这种影响在重新进食后是可逆的。
