Gahmberg C G, Kotovuori P, Tontti E
Department of Biochemistry, University of Helsinki, Finland.
APMIS Suppl. 1992;27:39-52.
During the past few years it has become increasingly evident that specific oligosaccharides in glycoproteins/glycolipids may play a central role in mammalian cell adhesion. This review deals with two of the best studied systems, the interaction of sperm cells with the Zona pellucida layer surrounding mammalian eggs, and the binding of leukocytes to endothelial cells. In the sperm cell-Zona pellucida system, it is known that a specific oligosaccharide(s) in the Zona pellucida glycoprotein 3 is responsible for binding. In the leukocyte-endothelial cell interaction, sialyl Le(x), sialyl Le(a), sulfatides, and other less well-defined sugar structures are involved in cellular binding. Oligosaccharides involved in these adhesion events may turn out to have clinically important applications.
在过去几年中，越来越明显的是，糖蛋白/糖脂中的特定寡糖可能在哺乳动物细胞黏附中起核心作用。本综述涉及两个研究得最为深入的系统，即精子细胞与围绕哺乳动物卵子的透明带层之间的相互作用，以及白细胞与内皮细胞的结合。在精子细胞 - 透明带系统中，已知透明带糖蛋白3中的一种特定寡糖负责结合。在白细胞 - 内皮细胞相互作用中，唾液酸化路易斯x、唾液酸化路易斯a、硫脂以及其他定义不太明确的糖结构参与细胞结合。参与这些黏附事件的寡糖可能会有重要的临床应用。
