Malik A B
Department of Physiology and Cell Biology (A-66), Albany Medical College, NY 12208.
New Horiz. 1993 Feb;1(1):37-51.
Adhesion molecules on the endothelium and leukocytes are involved in mediating cell-cell adhesion, which is an initial step in the leukocyte migration response. These adhesion molecules, some of which are present constitutively and others that can be up-regulated in response to chemotactic and proinflammatory stimuli, regulate the trafficking of leukocytes across the vascular endothelial barrier. A basic mechanism of interaction between the endothelium and leukocytes involves CD11/CD18 integrins, which bind to members of the immunoglobulin super gene family-intercellular adhesion molecule (ICAM)-1 and ICAM-2. The interaction between CD11/CD18 integrins and ICAM-1 is required for leukocyte migration. The other important adhesive interaction between leukocytes and the endothelium involves binding of selectins to their endothelium carbohydrate counterreceptors on leukocytes. The selectin-mediated binding is involved in leukocyte "rolling," whereas CD11/CD18 integrins are responsible for strengthening and stabilizing the leukocyte adhesion. This review summarizes the current literature on leukocyte adhesion molecules, in particular, the endothelial cell interactions mediated by the CD11/CD18 integrins.
内皮细胞和白细胞上的黏附分子参与介导细胞间黏附，这是白细胞迁移反应的起始步骤。这些黏附分子，其中一些是组成性存在的，另一些可因趋化性和促炎刺激而上调，它们调节白细胞穿过血管内皮屏障的运输。内皮细胞和白细胞之间相互作用的一个基本机制涉及CD11/CD18整合素，其与免疫球蛋白超基因家族成员细胞间黏附分子（ICAM）-1和ICAM-2结合。白细胞迁移需要CD11/CD18整合素与ICAM-1之间的相互作用。白细胞与内皮细胞之间另一个重要的黏附相互作用涉及选择素与其在白细胞上的内皮碳水化合物反受体的结合。选择素介导的结合参与白细胞“滚动”，而CD11/CD18整合素负责增强和稳定白细胞黏附。本综述总结了目前关于白细胞黏附分子的文献，特别是由CD11/CD18整合素介导的内皮细胞相互作用。
