12-十四酰佛波醇-13-乙酸酯诱导人肺鳞癌细胞分化。
12-O-tetradecanoylphorbol 13-acetate induced differentiation in human lung squamous carcinoma cells.
作者信息
Rabiasz G J, Langdon S P, Anderson L, Ritchie A A, Miller W R, Smyth J F
机构信息
ICRF Medical Oncology Unit, Western General Hospital, Edinburgh, UK.
出版信息
Br J Cancer. 1992 Sep;66(3):439-43. doi: 10.1038/bjc.1992.293.
Abstract
Three human lung squamous carcinoma cell lines (NX002, CX140 and CX143) demonstrate features of squamous differentiation including involucrin synthesis and competence to form cornified envelopes. 12-O-Tetradecanoylphorbol 13-acetate inhibits growth of these cell lines and this growth inhibition is associated with enhanced differentiation.
摘要
三种人肺鳞癌细胞系（NX002、CX140和CX143）表现出鳞状分化的特征，包括合成兜甲蛋白和形成角化包膜的能力。十四酰佛波醇-13-乙酸酯抑制这些细胞系的生长，且这种生长抑制与分化增强有关。
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