Gatter K C, Dunnill M S, Van Muijen G N, Mason D Y
J Clin Pathol. 1986 Sep;39(9):950-4. doi: 10.1136/jcp.39.9.950.
Ninety four pulmonary neoplasms were examined immunocytochemically with two or three different monoclonal antibodies against the intermediate filament proteins cytokeratin, neurofilament, vimentin, and desmin. In normal tissues these have a different and non-overlapping distribution, and it is generally believed that tumours maintain the same pattern of expression as the tissues from which they arise. In this report, however, the coexpression of at least two (and less commonly three or four) different intermediate filaments was seen in 40% (37 of 94) of the cases of lung cancer. These results, especially if confirmed in other common types of human malignancy, have considerable implications for the use of anti-intermediate filament antibodies in diagnostic pathology.
采用两种或三种针对中间丝蛋白细胞角蛋白、神经丝、波形蛋白及结蛋白的不同单克隆抗体，对94例肺肿瘤进行免疫细胞化学检查。在正常组织中，这些蛋白具有不同且不重叠的分布，一般认为肿瘤保持与其起源组织相同的表达模式。然而，在本报告中，40%（94例中的37例）肺癌病例中可见至少两种（较少见三种或四种）不同中间丝的共表达。这些结果，尤其是若能在其他常见人类恶性肿瘤中得到证实，对于抗中间丝抗体在诊断病理学中的应用具有重要意义。
