抗雄激素。I. 2-氮杂孕烷和2-氧杂孕烷类固醇。
Antiandrogen. I. 2-azapregnane and 2-oxapregnane steroids.
作者信息
Shibata K, Takegawa S, Koizumi N, Yamakoshi N, Shimazawa E
机构信息
Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1992 Apr;40(4):935-41. doi: 10.1248/cpb.40.935.
PMID:1381997
Abstract
2-Azachlormadinone acetate (5a, 17-acetoxy-6-chloro-2-azapregna-4,6-diene- 3,20-dione), 2-oxachlormadinone acetate (6, 17-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione) and the derivatives were prepared as potential antiandrogenic agents. Biological evaluation showed that 5a and 6 had a potent antiandrogenic activity when tested in the castrated male rat.
摘要
2-氮杂氯地孕酮醋酸酯（5α,17-乙酰氧基-6-氯-2-氮杂孕甾-4,6-二烯-3,20-二酮）、2-氧杂氯地孕酮醋酸酯（6,17-乙酰氧基-6-氯-2-氧杂孕甾-4,6-二烯-3,20-二酮）及其衍生物被制备作为潜在的抗雄激素剂。生物学评价表明，5α和6在去势雄性大鼠中测试时具有强效抗雄激素活性。
Zotero 插件