Takegawa S, Koizumi N, Mieda M, Shibata K
Research Department, Teikoku Hormone Mfg. Co. Ltd., Kawasaki, Japan.
Chem Pharm Bull (Tokyo). 1996 Apr;44(4):746-8. doi: 10.1248/cpb.44.746.
11-Oxachlormadinone acetate (17-acetoxy-6-chloro-11-oxapregna-4,6-diene-3,20-dione) and 2,11-dioxachlormadinone acetate (17-acetoxy-6-chloro-2,11-dioxapregna-4,6-diene-3,20-dione) were prepared as potential antiandrogenic agents. The effect of the latter compound on antiandrogenic activity when tested in the castrated rat was shown to be more potent than that of the parent compound, chlormadinone acetate.
11-氧代氯地孕酮醋酸酯（17-乙酰氧基-6-氯-11-氧杂孕甾-4,6-二烯-3,20-二酮）和2,11-二氧代氯地孕酮醋酸酯（17-乙酰氧基-6-氯-2,11-二氧杂孕甾-4,6-二烯-3,20-二酮）被制备为潜在的抗雄激素药物。在去势大鼠中进行测试时，后一种化合物的抗雄激素活性作用比母体化合物醋酸氯地孕酮更强。
