Boix F, Mattioli R, Adams F, Huston J P, Schwarting R K
Institute of Physiological Psychology I, University of Düsseldorf, Germany.
Eur J Pharmacol. 1992 May 27;216(1):103-7. doi: 10.1016/0014-2999(92)90215-p.
Microdialysis was used to monitor changes in dopamine release in the neostriatum and nucleus accumbens after peripheral administration of substance P in freely moving rats. Substance P in a dose of 50 micrograms/kg produced a steady moderate increase in dopamine levels in the neostriatum, which persisted for at least 5 h. In contrast, a dose of 250 micrograms/kg caused an acute increase in dopamine levels in the nucleus accumbens, which lasted about 2 h. These data suggest that the peripheral administration of substance P can influence dopamine release in mesolimbic and mesostriatal terminals.
