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Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis: confirmation of trisomy 7 in uncultured cells.

作者信息

Fletcher J A, Henkle C, Atkins L, Rosenberg A E, Morton C C

机构信息

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

出版信息

Genes Chromosomes Cancer. 1992 Apr;4(3):264-6. doi: 10.1002/gcc.2870040312.

DOI:10.1002/gcc.2870040312
PMID:1382569
Abstract

Pigmented villonodular synovitis (PVNS) is a proliferative lesion of disputed genesis. Recently, we reported trisomy 7 in short-term cultures of 1 PVNS. In the present report, we describe another specimen of PVNS in which 9 of 26 (35 percent) metaphase cells demonstrated trisomy 7 when analyzed after 3-15 days of tissue culture. In situ hybridization analysis, with a biotinylated probe to chromosome 7 alpha-satellite DNA, revealed trisomy 7 in 53 of 200 uncultured cells from this PVNS sample. Our findings indicate that trisomy 7 is a nonrandom aberration that arises in vivo in PVNS.

摘要

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