Casali M, Truglio F, Milone G, Di Raimondo F, Parrinello G, Maserati E, Pasquali F
Biologia Generale e Genetica Medica, Università di Pavia, Italy.
Genes Chromosomes Cancer. 1992 Apr;4(3):269-70. doi: 10.1002/gcc.2870040314.
A female patient with chronic myelocytic leukemia (CML) in chronic phase after busulfan and interferon treatment had four different cell lines in her bone marrow. In addition to cells with a normal karyotype there were cells with the Philadelphia chromosome (Ph1), cells with trisomy 8 and Ph1, and cells with trisomy 8 as the sole anomaly.