Ishida Y, Honda H, Watanabe T X
Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan.
Br J Pharmacol. 1992 Aug;106(4):764-5. doi: 10.1111/j.1476-5381.1992.tb14409.x.
A Ca(2+)-sensitive electrode was used to measure the Ca2+ concentration of the medium containing the heavy fraction of the fragmented sarcoplasmic reticulum (SR) prepared from guinea-pig psoas muscle. Among K(+)-channel blockers tested, 4-aminopyridine (4-AP), tetraethylammonium (TEA) and charybdotoxin elicited Ca2+ release from the SR, but apamin and glibenclamide did not. These results suggest that a reduction of SR K+ conductance leads to Ca2+ release from the SR.
使用钙离子敏感电极测量含有从豚鼠腰大肌制备的破碎肌浆网（SR）重组分的培养基中的钙离子浓度。在所测试的钾离子通道阻滞剂中，4-氨基吡啶（4-AP）、四乙铵（TEA）和大蝎毒素能引起肌浆网释放钙离子，但蜂毒明肽和格列本脲则不能。这些结果表明，肌浆网钾离子电导的降低会导致肌浆网释放钙离子。
