Kobayashi M, Ishida Y, Shoji N, Ohizumi Y
Mitsubishi-Kasei Institute of Life Sciences, Tokyo, Japan.
J Pharmacol Exp Ther. 1988 Aug;246(2):667-73.
[8]-Gingerol (gingerol), a component of ginger, produced a concentration-dependent positive inotropic effect on guinea pig isolated left atria at concentrations of 1 X 10(-6) to 3 X 10(-5) M. Gingerol also exhibited positive inotropic and chronotropic effects on guinea pig right atria. The gingerol-induced inotropic effect was abolished by ryanodine, but was little affected by propranolol, chlorpheniramine, cimetidine, tetrodotoxin, diltiazem or reserpine. The time to peak tension and relaxation time within a single contraction were shortened by gingerol (1 X 10(-5) M) as well as isoproterenol, whereas they were prolonged by BAY K 8644. In guinea pig isolated atrial cells, gingerol (3 X 10(-6) M) caused an increase in the degree and the rate of longitudinal contractions. In guinea pig left atria, gingerol (1 X 10(-6) to 3 X 10(-5) M) gave little influence on the action potential, although it increased the contractile force of the atria. The whole-cell patch-clamp experiments showed that the slow inward current was little affected by gingerol (1 X 10(-6) to 3 X 10(-5) M) in voltage-clamped guinea pig cardiac myocytes. The measurement of extravesicular Ca++ concentration using a Ca++ electrode indicated that gingerol (3 X 10(-6) to 3 X 10(-5) M) accelerated the Ca++ uptake of fragmented sarcoplasmic reticulum (SR) prepared from canine cardiac muscle in a concentration-dependent manner.(ABSTRACT TRUNCATED AT 250 WORDS)
[8]-姜辣素（姜酚）是生姜的一种成分，在浓度为1×10⁻⁶至3×10⁻⁵M时，对豚鼠离体左心房产生浓度依赖性正性肌力作用。姜辣素对豚鼠右心房也表现出正性肌力和变时作用。姜辣素诱导的肌力作用被ryanodine消除，但普萘洛尔、氯苯那敏、西咪替丁、河豚毒素、地尔硫䓬或利血平对其影响较小。姜辣素（1×10⁻⁵M）和异丙肾上腺素均可缩短单次收缩的张力峰值时间和舒张时间，而BAY K 8644则使其延长。在豚鼠离体心房细胞中，姜辣素（3×10⁻⁶M）可导致纵向收缩的程度和速率增加。在豚鼠左心房中，姜辣素（1×10⁻⁶至3×10⁻⁵M）对动作电位影响较小，尽管它增加了心房的收缩力。全细胞膜片钳实验表明，在电压钳制的豚鼠心肌细胞中，姜辣素（1×10⁻⁶至3×10⁻⁵M）对慢内向电流影响较小。使用Ca⁺⁺电极测量细胞外Ca⁺⁺浓度表明，姜辣素（3×10⁻⁶至3×10⁻⁵M）以浓度依赖性方式加速了从犬心肌制备的破碎肌浆网（SR）对Ca⁺⁺的摄取。（摘要截断于250字）
