Sad S, Rao K, Arora R, Talwar G P, Raghupathy R
National Institute of Immunology, New Delhi, India.
Immunology. 1992 Aug;76(4):599-603.
A gonadotropin-releasing hormone (GnRH)-based vaccine is being developed as a method for non-surgical immunotherapy as immunization with this vaccine results in atrophy of the prostate. This vaccine, a conjugate of GnRH and diphtheria toxoid (DT), provides a unique hapten-carrier system for investigating the influence of carrier presensitization on antibody responses to self haptens. In a recent communication we showed that preimmunization with carriers diphtheria toxoid and tetanus toxoid results in a strain-dependent inhibition of anti-GnRH responses in mice and that T cells from carrier-presensitized mice are responsible for anti-haptenic suppression. In the present report we describe a strategy for bypassing DT-induced epitopic suppression using a T-helper epitope from DT.
一种基于促性腺激素释放激素（GnRH）的疫苗正在被开发作为一种非手术免疫疗法，因为用这种疫苗免疫会导致前列腺萎缩。这种疫苗是GnRH与白喉类毒素（DT）的偶联物，为研究载体预致敏对自身半抗原抗体反应的影响提供了独特的半抗原-载体系统。在最近的一篇通讯中，我们表明用载体白喉类毒素和破伤风类毒素进行预免疫会导致小鼠体内抗GnRH反应出现品系依赖性抑制，并且来自载体预致敏小鼠的T细胞是抗半抗原抑制的原因。在本报告中，我们描述了一种使用来自DT的T辅助表位绕过DT诱导的表位抑制的策略。
