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关于抗马头皮屑反应素理化性质的研究。

Studies on the physico-chemical properties of reagin to horse dandruff.

作者信息

STANWORTH D R

出版信息

Immunology. 1959 Oct;2(4):384-402.

PMID:13833809
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423962/
Abstract

Human allergic serum has been fractionated by: (1) Chromatography on diethyl amino ethyl cellulose columns. (2) Ultracentrifugation in buffered sucrose gradients. Passive transfer tests with the fractions showed skin sensitizing activity to horse dandruff allergen to be associated with an electrophoretic gamma-globulin component possessing a 7S sedimentation constant. The difficulties encountered in the use of the chromatographic procedure for obtaining potent reagin preparations are discussed.

摘要

人过敏性血清已通过以下方法进行分级分离

（1）在二乙氨基乙基纤维素柱上进行色谱分析。（2）在缓冲蔗糖梯度中进行超速离心。用这些分级分离物进行的被动转移试验表明，对马头皮屑过敏原的皮肤致敏活性与具有7S沉降常数的电泳γ球蛋白成分有关。文中讨论了在使用色谱法获得高效反应素制剂过程中遇到的困难。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a4/1423962/22a402060c83/immunology00467-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a4/1423962/ab5a3cc1f89b/immunology00467-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a4/1423962/22a402060c83/immunology00467-0109-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a4/1423962/ab5a3cc1f89b/immunology00467-0108-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64a4/1423962/22a402060c83/immunology00467-0109-a.jpg

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1
Studies on the physico-chemical properties of reagin to horse dandruff.关于抗马头皮屑反应素理化性质的研究。
Immunology. 1959 Oct;2(4):384-402.
2
Physico-chemical studies on the reagin to horse dandruff.关于马头皮屑反应素的物理化学研究。
Acta Allergol Suppl (Copenh). 1960;7:48-55.
3
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本文引用的文献

1
The distribution of reagins in the serum protein fractions obtained by continuous zone electrophoresis.通过连续区带电泳获得的血清蛋白组分中反应素的分布。
Acta Allergol. 1955;8(4):339-48. doi: 10.1111/j.1398-9995.1955.tb03579.x.
2
The isolation and identification of horse-dandruff allergen.马头皮屑过敏原的分离与鉴定。
Biochem J. 1957 Mar;65(3):582-98. doi: 10.1042/bj0650582.
3
[Immunoelectrophoretic method for the analysis of mixtures of antigenic substances].[用于分析抗原物质混合物的免疫电泳法]
J Exp Med. 1964 Jul 1;120(1):31-43. doi: 10.1084/jem.120.1.31.
4
The association of skin-sensitizing antibody with the beta 2A-globulins in sera from ragweed-sensitive patients.豚草过敏患者血清中皮肤致敏抗体与β2A球蛋白的关联。
J Exp Med. 1963 Apr 1;117(4):603-20. doi: 10.1084/jem.117.4.603.
5
Human reagins: appraisal of the properties of the antibody of immediate-type hypersensitivity.人反应素：速发型超敏反应抗体特性的评估
Bacteriol Rev. 1972 Sep;36(3):311-60. doi: 10.1128/br.36.3.311-360.1972.
6
Immunochemistry of IgE.免疫球蛋白E的免疫化学
Proc R Soc Med. 1969 Sep;62(9):971-4. doi: 10.1177/003591576906200945.
Biochim Biophys Acta. 1955 May;17(1):67-74. doi: 10.1016/0006-3002(55)90320-6.
4
Immunochemical studies of antitoxin produced in normal and allergic individuals hyperimmunized with diphtheria toxoid. IV. Differences between human precipitating and non-precipitating skin-sensitizing diphtheria antitoxin as shown by electrophoresis.对白喉类毒素进行超免疫的正常个体和过敏个体所产生的抗毒素的免疫化学研究。IV. 电泳显示的人沉淀性和非沉淀性皮肤致敏白喉抗毒素之间的差异。
J Exp Med. 1954 Jun 1;99(6):577-88. doi: 10.1084/jem.99.6.577.