Zelop C, Nadel A, Frigoletto F D, Pauker S, MacMillan M, Benacerraf B R
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts.
Obstet Gynecol. 1992 Oct;80(4):693-4.
To investigate the relationship between elevated maternal serum alpha-fetoprotein (MSAFP) and abnormal placental adherence (placenta accreta/percreta/increta).
We reviewed the MSAFP levels of 11 women who had cesarean hysterectomies because of placenta accreta/percreta/increta. The control group consisted of 14 women who delivered by cesarean because of placenta previa but who had no abnormal placental adherence.
Five of the 11 women with placenta accreta/percreta/increta had elevated MSAFP, whereas all 14 controls had normal levels.
These results indicate a significant association between elevated MSAFP and placenta accreta/percreta/increta (P = .017). Patients with an unexplained elevation of MSAFP as well as placenta previa may be at increased risk for abnormal placental adherence.
探讨孕妇血清甲胎蛋白（MSAFP）升高与异常胎盘粘连（胎盘植入/穿透性胎盘植入/胎盘粘连植入）之间的关系。
我们回顾了11例因胎盘植入/穿透性胎盘植入/胎盘粘连植入而行剖宫产子宫切除术的女性的MSAFP水平。对照组由14例因前置胎盘而行剖宫产但无异常胎盘粘连的女性组成。
11例胎盘植入/穿透性胎盘植入/胎盘粘连植入的女性中有5例MSAFP升高，而所有14例对照组的MSAFP水平均正常。
这些结果表明MSAFP升高与胎盘植入/穿透性胎盘植入/胎盘粘连植入之间存在显著关联（P = 0.017）。MSAFP原因不明升高且合并前置胎盘的患者可能有异常胎盘粘连的风险增加。
