能量偶联反应的研究。通过分离的三磷酸腺苷合酶制剂进行三磷酸腺苷的净合成：硫辛酸和不饱和脂肪酸的作用。
Studies of energy-linked reactions. Net synthesis of adenosine triphosphate by isolated adenosine triphosphate synthase preparations: a role for lipoic acid and unsaturated fatty acids.
作者信息
Griffiths D E
出版信息
Biochem J. 1976 Dec 15;160(3):809-12. doi: 10.1042/bj1600809.
Abstract
ATP synthase preparations [complex V, proton-translocatin ATPase (adenosine triphosphatase) and oligomycin-sensitive ATPase ] contain stoicheiometric amounts of lipoic acid residues (up to 6mol of lipoic acid/mol of ATPase complex) and catalyse net ATP synthesis in an uncoupler-and oligomycin-sensitive reaction utilizing dihydrolipoate, oleoyl-CoA and oleic acid, or in a reaction utilizing oleoyl-S-lipoate. The terminal reactions of oxidative phosphorylation are thus analogous to those of substrate-level phosphorylation.
摘要
ATP合酶制剂[复合体V、质子转运ATP酶（腺苷三磷酸酶）和寡霉素敏感ATP酶]含有化学计量的硫辛酸残基（每摩尔ATP酶复合体中硫辛酸含量高达6摩尔），并在一种对解偶联剂和寡霉素敏感的反应中催化净ATP合成，该反应利用二氢硫辛酸盐、油酰辅酶A和油酸，或者在一个利用油酰-S-硫辛酸的反应中进行。因此，氧化磷酸化的末端反应类似于底物水平磷酸化的反应。
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