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本文引用的文献

1
A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II.一种与胃肠道癌相关的单克隆抗体定义抗原是一种含有唾液酸化乳糖-N-岩藻五糖II的神经节苷脂。
J Biol Chem. 1982 Dec 10;257(23):14365-9.
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Effects of monoclonal antibody immunotherapy on patients with gastrointestinal adenocarcinoma.单克隆抗体免疫疗法对胃肠道腺癌患者的影响。
J Biol Response Mod. 1984;3(2):138-50.
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Immunoglobulin E and the eczema-asthma syndrome in early childhood.免疫球蛋白E与儿童早期湿疹-哮喘综合征
Lancet. 1982 Jan 9;1(8263):72-4. doi: 10.1016/s0140-6736(82)90213-6.
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Mechanisms of rabies virus neutralization by glycoprotein-specific monoclonal antibodies.狂犬病病毒糖蛋白特异性单克隆抗体的中和机制
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Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression.一种与黑色素瘤肿瘤进展早期相关抗原的分子克隆与特性分析
Cancer Res. 1988 Jun 1;48(11):2955-62.
7
Identification of NGF receptor in chromatin of melanoma cells using monoclonal antibody to cell surface NGF receptor.
Biochem Biophys Res Commun. 1986 Oct 15;140(1):174-80. doi: 10.1016/0006-291x(86)91073-9.
8
Chromatin binding of epidermal growth factor, nerve growth factor, and platelet-derived growth factor in cells bearing the appropriate surface receptors.在带有相应表面受体的细胞中，表皮生长因子、神经生长因子和血小板衍生生长因子与染色质的结合。
Proc Natl Acad Sci U S A. 1986 Jun;83(11):3728-32. doi: 10.1073/pnas.83.11.3728.
9
Epidermal growth factor (EGF) and monoclonal antibody to cell surface EGF receptor bind to the same chromatin receptor.表皮生长因子（EGF）和细胞表面EGF受体的单克隆抗体与同一染色质受体结合。
Arch Biochem Biophys. 1989 Feb 1;268(2):456-64. doi: 10.1016/0003-9861(89)90313-5.
10
Selective chromosomal damage and cytotoxicity of 125I-labeled monoclonal antibody 17-1a in human cancer cells.
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针对细胞表面碳水化合物Y决定簇的单克隆抗体的核转位

Nuclear translocation of monoclonal antibody directed against cell-surface carbohydrate Y determinant.

作者信息

Rakowicz-Szulczynska E M, Steplewski Z, Koprowski H

机构信息

Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania.

出版信息

Am J Pathol. 1992 Oct;141(4):937-47.

PMID:1384341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1886628/
Abstract

Monoclonal antibody (MAb) Br 15-6A directed against the carbohydrate Y determinant expressed on tumor cells was found to be internalized and translocated to the nucleus of SK Br 5 breast carcinoma and SW 1116 and SW 707 colorectal carcinoma cells. Intracellular localization of MAb Br 15-6A was determined by cell fraction and by indirect immunofluorescence staining. Internalization of MAb Br 15-6A seems to be mediated by a specific cell surface protein of M(r) 108,000 in colorectal carcinoma cells and M(r) 92,000-96,000 in breast carcinoma cells. The MAb Br 15-6A precipitates an 88,000 M(r) chromatin protein and appears to be bound specifically to two EcoRI-digested and two HincII-chromatin fragments. Another MAb against the Y determinant (MAb Br 55.2) recognizes the same antigens as MAb Br 15-6A, but is not internalized.

摘要

发现针对肿瘤细胞上表达的碳水化合物Y决定簇的单克隆抗体（MAb）Br 15-6A可被内化并转移至SK Br 5乳腺癌细胞以及SW 1116和SW 707结肠癌细胞的细胞核。通过细胞分级分离和间接免疫荧光染色确定了MAb Br 15-6A在细胞内的定位。MAb Br 15-6A的内化似乎由结肠癌细胞中分子量为108,000的特定细胞表面蛋白介导，在乳腺癌细胞中则由分子量为92,000 - 96,000的特定细胞表面蛋白介导。MAb Br 15-6A沉淀出一种分子量为88,000的染色质蛋白，并且似乎特异性结合于两个经EcoRI消化和两个经HincII消化的染色质片段。另一种针对Y决定簇的单克隆抗体（MAb Br 55.2）识别与MAb Br 15-6A相同的抗原，但不会被内化。