Ding L, Balzarini J, Schols D, Meunier B, de Clercq E
Laboratoire de Chimie de Coordination du CNRS, Toulouse, France.
Biochem Pharmacol. 1992 Oct 20;44(8):1675-9. doi: 10.1016/0006-2952(92)90486-3.
A series of cationic metalloporphyrin-ellipticine complexes were found to inhibit the cytopathicity of human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus in MT-4 cells at concentrations ranging from 1.4 to 17 micrograms/mL, i.e. at a concentration that was 2.5-30-fold below the cytotoxicity threshold. These compounds were also found to inhibit syncytium formation between persistently HIV-1-infected HUT-78 and uninfected Molt/4 cells, to interfere with HIV-1 binding to the cells, and to suppress HIV-1-associated reverse transcriptase activity.
一系列阳离子金属卟啉-玫瑰树碱复合物被发现能够在1.4至17微克/毫升的浓度范围内抑制人免疫缺陷病毒1型（HIV-1）和猴免疫缺陷病毒在MT-4细胞中的细胞病变效应，即该浓度比细胞毒性阈值低2.5至30倍。这些化合物还被发现能够抑制持续感染HIV-1的HUT-78细胞与未感染的Molt/4细胞之间的合胞体形成，干扰HIV-1与细胞的结合，并抑制HIV-1相关的逆转录酶活性。
