Pierzchalski P, Nakamura T, Takehara T, Koj A
Institute of Molecular Biology, Jagiellonian University, Krakow, Poland.
Growth Factors. 1992;7(2):161-5. doi: 10.3109/08977199209046405.
Human recombinant hepatocyte growth factor (HGF) added to primary cultures of rat hepatocytes stimulates synthesis of some acute phase proteins, especially alpha-2-macroglobulin. As indicated by changes in mRNA abundance HGF increases alpha-2-macroglobulin production at the pretranslational level. Interleukin-6, the main acute-phase cytokine, does not show synergy with HGF in enhancing synthesis of alpha-2-macroglobulin, and inhibits HGF-induced DNA-synthesis. On the other hand, dexamethasone potentiates the effects of HGF on synthesis of DNA and acute phase proteins by cultured rat hepatocytes.
添加到大鼠肝细胞原代培养物中的人重组肝细胞生长因子（HGF）可刺激某些急性期蛋白的合成，尤其是α-2-巨球蛋白。正如mRNA丰度变化所示，HGF在翻译前水平增加α-2-巨球蛋白的产生。主要的急性期细胞因子白细胞介素-6在增强α-2-巨球蛋白合成方面不与HGF显示协同作用，并且抑制HGF诱导的DNA合成。另一方面，地塞米松增强HGF对培养的大鼠肝细胞DNA合成和急性期蛋白合成的作用。
