19例甲状腺乳头状癌的细胞遗传学研究

Cytogenetic studies on 19 papillary thyroid carcinomas.

作者信息

Antonini P, Vénuat A M, Caillou B, Berger R, Schlumberger M, Bernheim A, Parmentier C

机构信息

CNRS URA 1158, Laboratoire de Cytogénétique et Génétique Oncologiques, INSERM U66, Hôpital Saint-Louis, Paris, France.

出版信息

Genes Chromosomes Cancer. 1992 Oct;5(3):206-11. doi: 10.1002/gcc.2870050306.

DOI:10.1002/gcc.2870050306

PMID:1384672

Abstract

Short-term cultures from 19 papillary thyroid adenocarcinomas revealed clonal numerical and/or structural chromosomal changes in 13 tumors, nonclonal abnormalities in one tumor, and only normal karyotypes in five tumors. Clonal abnormalities of chromosome 10 were present in three tumors, two of which had the translocation t(7;10)(q35;q21). Numerical abnormalities of chromosome 17 were detected in two tumors.

摘要

对19例甲状腺乳头状腺癌进行短期培养，结果显示13例肿瘤存在克隆性染色体数目和/或结构改变，1例肿瘤存在非克隆性异常，5例肿瘤核型正常。3例肿瘤存在10号染色体克隆性异常，其中2例有t(7;10)(q35;q21)易位。2例肿瘤检测到17号染色体数目异常。