Teyssier J R, Liautaud-Roger F, Ferre D, Patey M, Dufer J
Laboratories of Histology-Embryology-Cytogenetics (INSERM U314), Reims, France.
Cancer Genet Cytogenet. 1990 Dec;50(2):249-63. doi: 10.1016/0165-4608(90)90184-c.
A cytogenetic study was performed in 63 thyroid tumors after a monolayer short-term culture. Clonal chromosomal changes were found in 47% of carcinomas and 31% of adenomas. Chromosome 7 was altered in 40% of cytogenetically abnormal tumors. The modal DNA index measured in 26 tumors was consistent with the chromosomal mode in 88% of cases. A quantitative morphometric analysis of nuclear features differentiated between diploid thyroid adenomas with or without a single translocation, which suggests that they have different biological properties. Clonal chromosomal changes were observed in 78% of carcinomas with an aggressive behavior, but only 28% of those had no risk factors. The two patients who died early had abnormalities of chromosome 7.
对63例甲状腺肿瘤进行单层短期培养后进行了细胞遗传学研究。在47%的癌和31%的腺瘤中发现了克隆性染色体改变。在40%细胞遗传学异常的肿瘤中，7号染色体发生了改变。在26个肿瘤中测量的模态DNA指数在88%的病例中与染色体模式一致。对核特征的定量形态分析区分了有或没有单一易位的二倍体甲状腺腺瘤，这表明它们具有不同的生物学特性。在78%具有侵袭性行为的癌中观察到克隆性染色体改变，但其中只有28%没有危险因素。两名早期死亡的患者有7号染色体异常。
