Antonini P, Vénuat A M, Linares G, Caillou B, Schlumberger M, Travagli J P, Berger R, Parmentier C
U66 INSERM, Institut Gustave-Roussy, Villejuif, France.
Cancer Genet Cytogenet. 1991 Apr;52(2):157-64. doi: 10.1016/0165-4608(91)90458-7.
Cytogenetic investigations using short-term cultures are reported in six thyroid adenomas. Clonal and nonclonal numerical chromosomal changes were present in two tumors. In two of the four remaining, nonclonal numerical and structural abnormalities were observed, whereas only normal karyotypes were found in the other two. Chromosome 10 and 17 were involved in several cases, although no common clonal changes could be detected. The present studies show that thyroid adenomas, benign tumors of an endocrine gland, may have chromosomal abnormalities, as described for other benign tumors.
本文报道了对6例甲状腺腺瘤进行的短期培养细胞遗传学研究。2例肿瘤中存在克隆性和非克隆性染色体数目改变。在其余4例中的2例观察到非克隆性染色体数目和结构异常，而另外2例仅发现正常核型。尽管未检测到常见的克隆性改变，但10号和17号染色体在多例中受累。目前的研究表明，作为一种内分泌腺的良性肿瘤，甲状腺腺瘤可能存在染色体异常，这与其他良性肿瘤的情况类似。
