Homasson J P, Pecking A, Roden S, Angebault M, Bonniot J P
Centre Hospitalier Spécialisé en Pneumologie, Chevilly-Larue, France.
Cryobiology. 1992 Oct;29(5):543-8. doi: 10.1016/0011-2240(92)90059-b.
The combined effect of cryotherapy and chemotherapy was studied in 12 patients with bronchial carcinoma. Radiolabeled (57 Co) Bleomycin (BLM) was injected intravenously and initial detection was carried out with a gamma-camera. Plasma half-life and clearance of 57 Co-BLM, as well as tumor/normal tissues ratios were calculated. The same protocol was performed 15 days later immediately after cryotherapy. A mean increase of 30% of radiolabeled BLM was found in the tumor area after cryotherapy, and pharmacokinetic data were significantly different after cryotherapy. The vascular component of cryodestruction offers an explanation for these results, with trapping of the anticancer drug in the tumor and immediately surrounding area due to vascular stasis. It seems that chemotherapy may be more effective after cryotherapy, and a multicenter study is in progress to evaluate the association of cryo-chemotherapy in France.
对12例支气管癌患者研究了冷冻疗法与化疗的联合效果。静脉注射放射性标记（57钴）博来霉素（BLM），并用γ相机进行初始检测。计算了57钴 - BLM的血浆半衰期和清除率，以及肿瘤/正常组织比值。15天后在冷冻疗法后立即按照相同方案进行操作。冷冻疗法后在肿瘤区域发现放射性标记的BLM平均增加了30%，并且冷冻疗法后的药代动力学数据有显著差异。冷冻破坏的血管成分可以解释这些结果，由于血管停滞，抗癌药物在肿瘤及其紧邻区域被截留。化疗似乎在冷冻疗法后可能更有效，目前正在进行一项多中心研究以评估法国冷冻化疗的联合效果。
