Hellekant C, Svanberg L
Acta Radiol Oncol Radiat Phys Biol. 1978;17(6):449-62. doi: 10.3109/02841867809128176.
Bronchial angiography was performed in 17 patients with advanced non-oat cell bronchogenic carcinoma. The patients were treated 1 to 5 times with infusions of 10 mg of mitomycin-C (MMC) into the tumor-feeding bronchial artery. All but 2 patients received in addition small doses of vincristine (intravenously) and bleomycin (intramuscularly) or only bleomycin to potentiate the effect of MMC. No major side effects occurred and the systemic toxicity was insignificant. An objective tumor reponse was encountered in 11/17 patients. Intraarterial chemotherapy is strictly local and therefore effective especially in patients with limited or locally advanced disease. In patients with more extensive disease an adjunctive therapy of a more regional or systemic modality must be given.
对17例晚期非燕麦细胞支气管源性癌患者进行了支气管造影。经肿瘤供血支气管动脉向患者输注10毫克丝裂霉素-C（MMC），治疗1至5次。除2例患者外，所有患者还额外接受了小剂量长春新碱（静脉注射）和博来霉素（肌肉注射），或仅接受博来霉素以增强MMC的效果。未出现严重副作用，全身毒性不明显。17例患者中有11例出现客观肿瘤反应。动脉内化疗严格局限于局部，因此尤其对局限性或局部晚期疾病患者有效。对于疾病范围更广的患者，必须给予更具区域性或全身性方式的辅助治疗。
