Shibata H
Department of Veterinary Anatomy, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan.
J Comp Neurol. 1992 Sep 1;323(1):117-27. doi: 10.1002/cne.903230110.
Subcortical projections to the anterior thalamic nuclei were studied in the rat, with special reference to projections from the mammillary nuclei, by retrograde and anterograde transport of wheat germ agglutinin conjugated to horseradish peroxidase. The medial mammillary nucleus (MM) projects predominantly ipsilaterally to the entire anterior thalamic nuclei, whereas the lateral mammillary nucleus projects bilaterally to the anterodorsal nucleus (AD) of the anterior thalamic nuclei. A topographic relationship was recognized between the MM and the anterior thalamic nuclei. The dorsal region of the pars mediana of the MM projects to the interanteromedial nucleus (IAM), whereas the ventral region projects to the rostral part of the anteromedial nucleus (AM). The dorsal and the ventral regions of the pars medialis project to the dorsomedial part of the AM at its caudal and rostral levels, respectively. The dorsomedial region of the pars lateralis projects to the ventral AM. The ventrolateral region of the pars lateralis projects to the ventral part of the anteroventral nucleus (AV) in such a manner that rostral cells project rostrally and caudal cells project caudally. The pars basalis projects predominantly ipsilaterally to the dorsolateral AV and bilaterally to the AD. The rostrolateral region of the pars posterior projects to the lateral AV, whereas the medial and the caudal regions of the pars posterior project to the dorsomedial AV. The rostrodorsal part of the nucleus reticularis thalami was found to project to the anterior thalamic nuclei; cells located rostrally in this part project to the IAM and AM, whereas cells located caudodorsally project to the AV and AD. The laterodorsal tegmental nucleus projects predominantly ipsilaterally to the AV, especially to its dorsolateral part. The present study demonstrates that subdivisions of the subcortical structures are connected to the subnuclei of the anterior thalamic nuclei, with a clear-cut topography arranged in the dorsoventral and the rostrocaudal dimensions.
利用与辣根过氧化物酶结合的小麦胚凝集素的逆行和顺行运输，在大鼠中研究了丘脑前核的皮质下投射，特别关注来自乳头体核的投射。内侧乳头体核（MM）主要同侧投射至整个丘脑前核，而外侧乳头体核双侧投射至丘脑前核的前背核（AD）。在MM与丘脑前核之间发现了一种拓扑关系。MM中份的背侧区域投射至内侧前间核（IAM），而腹侧区域投射至前内侧核（AM）的 Rostral 部分。内侧份的背侧和腹侧区域分别在其尾侧和 Rostral 水平投射至 AM 的背内侧部分。外侧份的背内侧区域投射至腹侧 AM。外侧份的腹外侧区域以 Rostral 细胞向 Rostral 方向投射、尾侧细胞向尾侧方向投射的方式投射至前腹核（AV）的腹侧部分。基底份主要同侧投射至背外侧 AV，双侧投射至 AD。后份的 Rostral 外侧区域投射至外侧 AV，而后份的内侧和尾侧区域投射至背内侧 AV。发现丘脑网状核的 Rostral 背侧部分投射至丘脑前核；该部分 Rostral 位置的细胞投射至 IAM 和 AM，而尾背侧位置的细胞投射至 AV 和 AD。外侧背侧被盖核主要同侧投射至 AV，尤其是其背外侧部分。本研究表明，皮质下结构的细分与丘脑前核的亚核相连，在背腹和前后维度上具有清晰的拓扑结构。
