School of Psychology, Cardiff University, 70 Park Place, Cardiff CF10 3AT, Wales, UK.
School of Psychology, Cardiff University, 70 Park Place, Cardiff CF10 3AT, Wales, UK.
Neurosci Biobehav Rev. 2022 Sep;140:104813. doi: 10.1016/j.neubiorev.2022.104813. Epub 2022 Aug 5.
After more than 80 years, Papez serial circuit remains a hugely influential concept, initially for emotion, but in more recent decades, for memory. Here, we show how this circuit is anatomically and mechanistically naïve as well as outdated. We argue that a new conceptualisation is necessitated by recent anatomical and functional findings that emphasize the more equal, working partnerships between the anterior thalamic nuclei and the hippocampal formation, along with their neocortical interactions in supporting, episodic memory. Furthermore, despite the importance of the anterior thalamic for mnemonic processing, there is growing evidence that these nuclei support multiple aspects of cognition, only some of which are directly associated with hippocampal function. By viewing the anterior thalamic nuclei as a multifunctional hub, a clearer picture emerges of extra-hippocampal regions supporting memory. The reformulation presented here underlines the need to retire Papez serially processing circuit.
经过 80 多年，帕佩兹级联回路仍然是一个极具影响力的概念，最初是关于情绪的，但在最近几十年，它又与记忆有关。在这里，我们展示了这个回路在解剖学和机制上是多么幼稚和过时。我们认为，最近的解剖学和功能发现强调了前丘脑核和海马结构之间更平等、更具协作性的工作关系，以及它们在支持情景记忆方面与新皮层的相互作用，这需要一种新的概念化。此外，尽管前丘脑核对记忆处理很重要，但越来越多的证据表明，这些核支持认知的多个方面，其中只有一些与海马体功能直接相关。通过将前丘脑核视为一个多功能枢纽，可以更清楚地了解支持记忆的海马体以外的区域。这里提出的重新表述强调了需要摒弃帕佩兹级联处理回路的观点。
