Andersson A, Sundman I, Marcusson J
Department of Internal Medicine, University of Umeå, Sweden.
Gerontology. 1992;38(3):127-32. doi: 10.1159/000213319.
The effect of age on serotonin uptake sites labeled with [3H]paroxetine was studied in two sets of brains. The first set included 28 subjects (19 males and 9 females) between the ages 0 and 100 years. The cortex of cingulate gyrus and the amygdala were studied. No age-related changes in binding capacity (Bmax) or binding affinity (Kd) were noted. In the second set, the frontal cortex and hypothalamus from 22 subjects (18 males and 4 females) between 16 and 75 years were studied. No age-related changes in the binding were observed. The interval between death and freezing of the tissue did not influence the binding. Regarding the [3H]paroxetine binding as an indirect marker for 5-HT terminals, the data suggest a stability of 5-HT terminals with increasing age in the human brain.
在两组大脑中研究了年龄对用[3H]帕罗西汀标记的5-羟色胺摄取位点的影响。第一组包括28名年龄在0至100岁之间的受试者（19名男性和9名女性）。研究了扣带回皮质和杏仁核。未发现结合能力（Bmax）或结合亲和力（Kd）与年龄相关的变化。在第二组中，研究了22名年龄在16至75岁之间的受试者（18名男性和4名女性）的额叶皮质和下丘脑。未观察到结合与年龄相关的变化。组织死亡与冷冻之间的间隔不影响结合。将[3H]帕罗西汀结合视为5-羟色胺终末的间接标记，数据表明人脑5-羟色胺终末随年龄增长具有稳定性。
