丘脑和脑桥中[¹²³I]FP-CIT 的外节段结合：在欧洲多中心健康对照者数据库中评估的性别和年龄依赖性。
Extrastriatal binding of [¹²³I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls.
机构信息
Department of Nuclear Medicine, University of Munich, Marchioninistr. 15, 81377, Munich, Germany,
出版信息
Eur J Nucl Med Mol Imaging. 2014 Oct;41(10):1938-46. doi: 10.1007/s00259-014-2785-8. Epub 2014 May 8.
PURPOSE
Apart from binding to the dopamine transporter (DAT), [(123)I]FP-CIT shows moderate affinity for the serotonin transporter (SERT), allowing imaging of both monoamine transporters in a single imaging session in different brain areas. The aim of this study was to systematically evaluate extrastriatal binding (predominantly due to SERT) and its age and gender dependencies in a large cohort of healthy controls.
METHODS
SPECT data from 103 healthy controls with well-defined criteria of normality acquired at 13 different imaging centres were analysed for extrastriatal binding using volumes of interest analysis for the thalamus and the pons. Data were examined for gender and age effects as well as for potential influence of striatal DAT radiotracer binding.
RESULTS
Thalamic binding was significantly higher than pons binding. Partial correlations showed an influence of putaminal DAT binding on measured binding in the thalamus but not on the pons. Data showed high interindividual variation in extrastriatal binding. Significant gender effects with 31 % higher binding in women than in men were observed in the thalamus, but not in the pons. An age dependency with a decline per decade (±standard error) of 8.2 ± 1.3 % for the thalamus and 6.8 ± 2.9 % for the pons was shown.
CONCLUSION
The potential to evaluate extrastriatal predominant SERT binding in addition to the striatal DAT in a single imaging session was shown using a large database of [(123)I]FP-CIT scans in healthy controls. For both the thalamus and the pons, an age-related decline in radiotracer binding was observed. Gender effects were demonstrated for binding in the thalamus only. As a potential clinical application, the data could be used as a reference to estimate SERT occupancy in addition to nigrostriatal integrity when using [(123)I]FP-CIT for DAT imaging in patients treated with selective serotonin reuptake inhibitors.
目的
除了与多巴胺转运体（DAT）结合外，[(123)I]FP-CIT 还对 5-羟色胺转运体（SERT）具有中等亲和力，可在单次成像过程中对不同脑区的两种单胺转运体进行成像。本研究的目的是系统评估大健康对照组中存在的纹外结合（主要由 SERT 引起）及其与年龄和性别相关的依赖性。
方法
使用基于体素的感兴趣区分析，对 13 个不同成像中心获得的 103 名具有明确正常标准的健康对照者的 SPECT 数据进行纹外结合分析，感兴趣区包括丘脑和脑桥。检查了性别和年龄的影响，以及纹状体 DAT 示踪剂结合的潜在影响。
结果
丘脑结合明显高于脑桥结合。偏相关分析显示，壳核 DAT 结合对丘脑测量结合有影响，但对脑桥无影响。数据显示纹外结合存在个体间的高度变异性。在丘脑部位观察到了明显的性别效应，女性结合比男性高 31%，但在脑桥部位则没有。还显示出与年龄相关的依赖性，每 10 年下降（±标准误差）为 8.2±1.3%，丘脑和 6.8±2.9%，脑桥。
结论
使用健康对照者的[(123)I]FP-CIT 扫描的大型数据库，显示了除纹状体 DAT 外，还可以在单次成像过程中评估纹外 SERT 结合的潜力。对于丘脑和脑桥，观察到放射性示踪剂结合随年龄的下降。仅在丘脑部位观察到性别效应。作为潜在的临床应用，当使用[(123)I]FP-CIT 对接受选择性 5-羟色胺再摄取抑制剂治疗的患者进行 DAT 成像时，这些数据可作为估计 SERT 占有率的参考，以及黑质纹状体的完整性。
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