Snead D B, Weltman A, Weltman J Y, Evans W S, Veldhuis J D, Varma M M, Teates C D, Dowling E A, Rogol A D
Curry School of Education, University of Virginia, Charlottesville 22903.
J Appl Physiol (1985). 1992 Jun;72(6):2149-56. doi: 10.1152/jappl.1992.72.6.2149.
We examined the relationships among reproductive hormone concentrations and bone mineral density (BMD) in 43 women runners classified as eumenorrheic (n = 24), oligomenorrheic (n = 8), or amenorrheic (n = 11). Results were compared with a eumenorrheic nonrunner control group (n = 11). Serum 17 beta-estradiol, progesterone, and dehydroepiandrosterone sulfate concentrations were determined in daily blood samples for 21 days, and integrated concentrations (areas under the curve) were calculated. BMD was assessed at the lumbar spine and proximal femur by dual-photon absorptiometry. As expected, 17 beta-estradiol, progesterone, and lumbar spine BMD were higher in the control and eumenorrheic runner groups than in the oligomenorrheic and amenorrheic runner groups (P less than 0.05). Progesterone concentration was significantly correlated with lumbar spine BMD in the eumenorrheic runners (r = 0.61). None of the steroid hormones was significantly related to BMD in the oligomenorrheic/amenorrheic group. The present data suggest that circulating levels of gonadal steroid hormones affect axial BMD in eumenorrheic runners.
我们研究了43名女性跑步者的生殖激素浓度与骨矿物质密度（BMD）之间的关系，这些女性跑步者被分为月经正常组（n = 24）、月经过少组（n = 8）或闭经组（n = 11）。将结果与月经正常的非跑步者对照组（n = 11）进行比较。在21天的每日血样中测定血清17β-雌二醇、孕酮和硫酸脱氢表雄酮浓度，并计算综合浓度（曲线下面积）。通过双能光子吸收法评估腰椎和股骨近端的骨密度。正如预期的那样，对照组和月经正常的跑步者组中的17β-雌二醇、孕酮和腰椎骨密度高于月经过少和闭经的跑步者组（P < 0.05）。月经正常的跑步者中，孕酮浓度与腰椎骨密度显著相关（r = 0.61）。在月经过少/闭经组中，没有一种甾体激素与骨密度显著相关。目前的数据表明，性腺甾体激素的循环水平影响月经正常的跑步者的轴向骨密度。
