Lane J D, Pickering C L, Hooper M L, Fagan K, Tyers M B, Emmett-Oglesby M W
Department of Pharmacology, Texas College of Osteopathic Medicine, Fort Worth 76107-2690.
Drug Alcohol Depend. 1992 Jun;30(2):151-62. doi: 10.1016/0376-8716(92)90020-d.
Ondansetron (GR38032F), a serotonin 5HT3 antagonist, is active in numerous behavioral paradigms and neurochemical systems. Since 5HT3 antagonists have been suggested as therapeutic agents for the treatment of drug abuse, the action of ondansetron on cocaine drug discrimination and self-administration paradigms in rats was investigated. Doses of ondansetron (0.001 - 1.0 mg/kg) had no effect on the discriminative stimulus properties of 10 mg/kg cocaine. In contrast SCH23390, a dopamine D1 antagonist known to block cocaine discrimination, acted as previously reported. Ondansetron did not augment the effects of SCH23390, but at higher doses, combinations of ondansetron and SCH23390 produced disruption of lever pressing in the presence of cocaine. Ondansetron (0.001-1.0 mg/kg) had no effect on the self-administration of various doses of cocaine, nor did it have any effect on reacquisition of cocaine self-administration in animals with a history of active administration followed by a period of abstinence. As before, SCH23390, known to block cocaine self-administration, acted as previously reported. Although other 5HT antagonists may prove to be efficacious in cocaine abuse, ondansetron appears unlikely to alter the subjective or rewarding stimulus properties of cocaine.
昂丹司琼（GR38032F），一种5-羟色胺5HT3拮抗剂，在众多行为范式和神经化学系统中具有活性。由于5HT3拮抗剂已被提议作为治疗药物滥用的治疗剂，因此研究了昂丹司琼对大鼠可卡因药物辨别和自我给药范式的作用。昂丹司琼剂量（0.001 - 1.0毫克/千克）对10毫克/千克可卡因的辨别刺激特性没有影响。相比之下，已知能阻断可卡因辨别的多巴胺D1拮抗剂SCH23390，其作用与先前报道的一致。昂丹司琼没有增强SCH23390的作用，但在较高剂量下，昂丹司琼和SCH23390的组合在有可卡因存在的情况下会导致杠杆按压中断。昂丹司琼（0.001 - 1.0毫克/千克）对各种剂量可卡因的自我给药没有影响，对有主动给药史随后有一段时间禁欲的动物重新获得可卡因自我给药也没有任何影响。和以前一样，已知能阻断可卡因自我给药的SCH23390，其作用与先前报道的一致。尽管其他5HT拮抗剂可能被证明对可卡因滥用有效，但昂丹司琼似乎不太可能改变可卡因的主观或奖赏刺激特性。
