Peltier R, Schenk S
Department of Psychology, Texas A&M University, College Station 77843.
Pharmacol Biochem Behav. 1991 May;39(1):133-6. doi: 10.1016/0091-3057(91)90410-4.
Recent data have supported a role for serotonin (5-HT) in the self-administration of cocaine by laboratory rats. More specifically, it has been suggested that 5-HT3 receptor antagonists may be useful in the treatment of drug abuse. To assess this possibility, we compared the effects of the 5-HT3 antagonist, GR38032F, with the dopamine D2 receptor blocker, haloperidol, on the intravenous self-administration of cocaine (0.5 mg/kg/infusion) in rats. The serotonin antagonist (0.01, 0.1 or 1.0 mg/kg, IP) failed to alter self-administration (0.5 mg/kg/infusion). In contrast, haloperidol (0.125 mg/kg, IP) increased responding for cocaine (0.5 mg/kg/infusion), and shifted the dose-response curve for cocaine self-administration to the right. These data fail to support a role for the serotonin 5-HT3 receptor system in the reinforcing properties of this psychostimulant. Rather, the 5-HT1 or 5-HT2 receptors may be the critical subtype.
近期数据支持血清素（5-羟色胺，5-HT）在实验大鼠自我注射可卡因过程中发挥作用。更具体地说，有人提出5-HT3受体拮抗剂可能对治疗药物滥用有用。为评估这种可能性，我们比较了5-HT3拮抗剂GR38032F与多巴胺D2受体阻滞剂氟哌啶醇对大鼠静脉注射可卡因（0.5毫克/千克/次注射）自我给药的影响。血清素拮抗剂（0.01、0.1或1.0毫克/千克，腹腔注射）未能改变自我给药情况（0.5毫克/千克/次注射）。相比之下，氟哌啶醇（0.125毫克/千克，腹腔注射）增加了对可卡因（0.5毫克/千克/次注射）的反应，并将可卡因自我给药的剂量-反应曲线向右移动。这些数据不支持血清素5-HT3受体系统在这种精神兴奋剂强化特性中发挥作用。相反，5-HT1或5-HT2受体可能是关键亚型。
