McMahon B J, Parkinson A J, Helminiak C, Wainwright R B, Bulkow L, Kellerman-Douglas A, Schoenberg S, Ritter D
Alaska Native Medical Center, Indian Health Service, Anchorage.
Gastroenterology. 1992 Aug;103(2):590-4. doi: 10.1016/0016-5085(92)90851-o.
The significance of antibody to hepatitis B core antigen (anti-HBc) present in a person's serum without hepatitis B surface antigen (HBsAg) or its antibody (anti-HBs) is unknown. Serum specimens from 281 persons initially positive only for anti-HBc by enzyme immunoassay (EIA) were retested by radioimmunoassay (RIA), and of these, 177 (63%) remained positive for anti-HBc by both assays. Of these 177 persons, 3 were positive for HBsAg, and 72 possessed low levels of anti-HBs [less than 10 sample ratio units; (SRU's)]. When persons positive for anti-HBc by EIA and RIA were given one 20-micrograms dose of plasma-derived hepatitis B vaccine and tested for anti-HBs 1 month later, a booster response was observed in 14 of 41 (34%) persons with low level anti-HBs and 3 of 50 (6%) persons negative for anti-HBs. Of those positive only for anti-HBc by EIA but negative by RIA, only 3 of 37 (8.1%) showed a booster response. Of those who completed the three-dose immunization series and did not show a booster response, 63 of 80 (78.8%) developed anti-HBs levels greater than 10 standard ratio unit. The majority of persons with isolated anti-HBc will have a primary rather than a booster response to hepatitis B vaccine.
在一个人的血清中存在乙肝核心抗原抗体（抗-HBc），但不存在乙肝表面抗原（HBsAg）或其抗体（抗-HBs），其意义尚不清楚。对281名最初通过酶免疫测定（EIA）仅抗-HBc呈阳性的人的血清标本进行放射免疫测定（RIA）重新检测，其中177人（63%）两种检测抗-HBc均呈阳性。在这177人中，3人HBsAg呈阳性，72人抗-HBs水平较低[低于10个样本比值单位；（SRU's）]。当通过EIA和RIA抗-HBc呈阳性的人接种一剂20微克的血浆源性乙肝疫苗，并在1个月后检测抗-HBs时，41名抗-HBs水平低的人中有14人（34%）出现加强反应，50名抗-HBs阴性的人中有3人（6%）出现加强反应。在那些仅通过EIA抗-HBc呈阳性但通过RIA呈阴性的人中，37人中有3人（8.1%）出现加强反应。在完成三剂免疫接种系列且未出现加强反应的人中，80人中有63人（78.8%）抗-HBs水平高于10个标准比值单位。大多数孤立抗-HBc患者对乙肝疫苗会产生初次反应而非加强反应。
