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是否受到保护?医护人员的乙肝疫苗接种状况及接种后的保护水平。

Protected or not? Hepatitis B vaccination status among healthcare workers and the level of protection post-vaccination.

作者信息

Manrai Manish, Harikrishnan P, Sahu Rajesh, Shergill S P S

机构信息

Professor, Department of Internal Medicine, Armed Forces Medical College, Pune, India.

Resident, Department of Internal Medicine, Armed Forces Medical College, Pune, India.

出版信息

Med J Armed Forces India. 2024 Dec;80(Suppl 1):S153-S159. doi: 10.1016/j.mjafi.2023.01.013. Epub 2023 Apr 10.

Abstract

BACKGROUND

Hepatitis B virus infection is one of the major concerns in global health care. With a far-reaching health, social, economic impact, preventive strategies form the cornerstone of its management. Knowledge about vaccination status and protection rendered thereof would aid in more wholesome management among highrisk population groups like healthcare workers. The aim of this study was to evaluate the Hepatitis B vaccination status among Healthcare workers (HCW) and the level of protection post-vaccination.

METHODS

During the study period a total of 420 HCWs were included in the study. The details of vaccination status was ascertained by an online questionnaire. Serum samples were evaluated for HBsAg status and Anti HBs titres to assess the level of protection against HBV infection. Those who were HBsAg negative, anti-HBc total was assessed.

RESULTS

Our study revealed a high vaccination status among HCWs, n-384 (93.2%). However, the percentage of HCWs who were completely vaccinated was low (56.3%). Most of the study population, n-395 (95.6%) had protective titres of anti-HBs which showed a declining trend with increasing duration since the last dose of the vaccine.

CONCLUSION

Hepatitis B infection continues to be an important health hazard with significant morbidity and mortality. Healthcare workers are at higher risk of contracting the infection. Merely considering the vaccination status without knowing the protective anti-HBs titres is to be discouraged as it has been observed that the protective antibody titres show a declining trend with time as even completely vaccinated individuals had non-protective levels of antibody titres.

摘要

背景

乙型肝炎病毒感染是全球医疗卫生领域的主要关注点之一。它具有深远的健康、社会和经济影响,预防策略是其管理的基石。了解疫苗接种状况及其提供的保护将有助于对医护人员等高风险人群进行更全面的管理。本研究的目的是评估医护人员的乙肝疫苗接种状况以及接种后的保护水平。

方法

在研究期间,共有420名医护人员纳入研究。通过在线问卷确定疫苗接种状况的详细信息。评估血清样本的乙肝表面抗原(HBsAg)状态和乙肝表面抗体(Anti-HBs)滴度,以评估针对乙肝病毒感染的保护水平。对HBsAg阴性者,评估抗-HBc总量。

结果

我们的研究显示医护人员的疫苗接种率较高,为384人(93.2%)。然而,完全接种疫苗的医护人员比例较低(56.3%)。大多数研究对象,即395人(95.6%)有抗-HBs保护性滴度,且自最后一剂疫苗接种后,随着时间延长,该滴度呈下降趋势。

结论

乙型肝炎感染仍然是一种重要的健康危害,具有显著的发病率和死亡率。医护人员感染该病毒的风险更高。不建议仅考虑疫苗接种状况而不了解保护性抗-HBs滴度,因为据观察,即使是完全接种疫苗的个体,其抗体滴度也会随着时间呈下降趋势,出现非保护性抗体滴度水平。

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本文引用的文献

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Clin Liver Dis (Hoboken). 2021 Oct 15;18(3):111-116. doi: 10.1002/cld.1125. eCollection 2021 Sep.
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Hepatitis B Immunisation in Health Care Workers.医护人员的乙肝免疫接种
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