Bassily S, Strickland G T, Abdel-Wahab M F, Esmat G E, Narooz S, el-Masry N A, Constantine N T, Struewing J P
US Naval Medical Research Unit No. 3, University Faculty of Medicine, Cairo, Egypt.
J Infect Dis. 1992 Aug;166(2):265-8. doi: 10.1093/infdis/166.2.265.
To determine whether chronic Schistosoma mansoni infection interferes with hepatitis B virus (HBV) immunization, 308 schoolchildren aged 6-12 years with no evidence of prior HBV infection (156 with active schistosomiasis) were vaccinated with three 5-micrograms injections of recombinant DNA-derived HBV vaccine. The vaccine was given in the deltoid muscle at time 0 and 1 and 7 months later. All vaccinees were examined 1 and 3 years after vaccination for quantitative antibody to hepatitis B surface antigen (anti-HBs). Seroconversion was detected in 284 vaccinated children (92%), of whom 271 had a good (51-300 mIU/mL) or excellent (greater than 300 mIU/mL) anti-HBs response. Sixteen other children (5%) had evidence of natural HBV infection (antibody to hepatitis B core antigen). Of those with good or excellent response, 99% retained high antibody titers for 3 years. Response was not influenced by S. mansoni infection. Hepatomegaly and splenomegaly were associated with reduced vaccine response.
为确定慢性曼氏血吸虫感染是否会干扰乙型肝炎病毒（HBV）免疫接种，对308名6至12岁无既往HBV感染证据的学童（156名患有活动性血吸虫病）进行了三次5微克重组DNA衍生HBV疫苗注射接种。疫苗分别在0月、1月和7个月后于三角肌注射。所有接种者在接种后1年和3年接受检查，检测乙型肝炎表面抗原定量抗体（抗-HBs）。284名接种儿童（92%）检测到血清转化，其中271名有良好（51 - 300 mIU/mL）或优异（大于300 mIU/mL）的抗-HBs反应。另有16名儿童（5%）有自然HBV感染证据（乙型肝炎核心抗原抗体）。在有良好或优异反应的儿童中，99%在3年内保持高抗体滴度。反应不受曼氏血吸虫感染影响。肝肿大和脾肿大与疫苗反应降低有关。
