Akamatsu H, Kurokawa I, Nishijima S, Asada Y
Department of Dermatology, Kansai Medical University, Osaka, Japan.
Dermatology. 1992;185(1):41-3. doi: 10.1159/000247401.
The effect of 1/10 minimal inhibitory concentrations (sub-MIC) of erythromycin (EM) on human neutrophil chemotactic factor production in comedonal bacteria, Propionibacterium acnes strains, Propionibacterium granulosum strains and coagulase-negative staphylococcus (CNS) strains was assayed using the Boyden chamber method. Sub-MIC of EM significantly suppressed neutrophil chemotactic factor production in all strains of P. acnes, P. granulosum and CNS. Our results suggest that sub-MIC of EM may have an anti-inflammatory action by reducing the inflammatory capacity of comedonal bacteria in inflammatory acne.
采用博伊登小室法测定了红霉素（EM）1/10最小抑菌浓度（亚抑菌浓度）对粉刺丙酸杆菌、颗粒丙酸杆菌及凝固酶阴性葡萄球菌（CNS）产生人中性粒细胞趋化因子的影响。EM的亚抑菌浓度能显著抑制所有粉刺丙酸杆菌、颗粒丙酸杆菌及CNS菌株产生中性粒细胞趋化因子。我们的结果表明，EM的亚抑菌浓度可能通过降低炎性痤疮中粉刺细菌的炎症能力而具有抗炎作用。
