Vegesna V, Withers H R, McBride W H, Holly F E
Department of Radiation Oncology, UCLA Medical Center 90024-1714.
Int J Radiat Oncol Biol Phys. 1992;23(5):977-81. doi: 10.1016/0360-3016(92)90902-t.
The influence of Adriamycin and Actinomycin D on the expression of residual damage following irradiation of mouse thorax was evaluated. Drugs were given i.v. at various times starting on the same day, up to 3 months after irradiation, and the mortality from lung damage up to 160 days or epilation up to 98 days after irradiation were noted. Adriamycin (1.2 mg/kg in two equal doses), which on its own did not cause pneumonitic deaths, did so when combined with doses of local thoracic radiation as small as 6 Gy. The dose effect factor was greater if Adriamycin was given at 1 or 2 months (1.68) rather than on the same day (1.49). A reduction in the latent period to death was also observed with a minimum period of 50-60 days after irradiation rather than the normal 80-160 days. Adriamycin enhanced the epilation response to radiation, but only at or above threshold radiation doses. There was no reduction in the latency. Actinomycin D had no dose-modifying effects on the radiation response of both lung and hair follicles. The interaction between irradiation and Adriamycin seen when the interval between the two modalities is long, as it was in this study, may be mechanistically similar to the "radiation recall" phenomenon described in the clinic.
评估了阿霉素和放线菌素D对小鼠胸部照射后残留损伤表达的影响。在照射当天开始后的不同时间静脉注射药物，直至照射后3个月，并记录照射后160天内因肺损伤导致的死亡率或98天内的脱毛率。阿霉素（1.2mg/kg，分两次等量给药）单独使用时不会导致肺炎死亡，但与低至6Gy的局部胸部辐射剂量联合使用时会导致肺炎死亡。如果阿霉素在照射后1或2个月给药（剂量效应因子为1.68），而不是在照射当天给药（剂量效应因子为1.49），剂量效应因子会更大。还观察到死亡潜伏期缩短，照射后最短为50 - 60天，而不是正常的80 - 160天。阿霉素增强了对辐射的脱毛反应，但仅在阈值辐射剂量及以上时。潜伏期没有缩短。放线菌素D对肺和毛囊的辐射反应没有剂量调节作用。正如本研究中所观察到的，当两种治疗方式之间的间隔时间较长时，照射与阿霉素之间的相互作用在机制上可能类似于临床上描述的“放射回忆”现象。
