转基因T细胞受体β链的表达增强了胶原诱导的关节炎。
Expression of a transgenic T cell receptor beta chain enhances collagen-induced arthritis.
作者信息
Mori L, Loetscher H, Kakimoto K, Bluethmann H, Steinmetz M
机构信息
Pharmaceutical Research New Technologies, F. Hoffmann-La Roche, Ltd., Basel, Switzerland.
出版信息
J Exp Med. 1992 Aug 1;176(2):381-8. doi: 10.1084/jem.176.2.381.
Abstract
SWR/J transgenic (tg) mice were generated expressing the TCR beta chain derived from an anticollagen type II (CII) arthritogenic T cell clone. The SWR/J strain was selected because it is resistant to collagen-induced arthritis (CIA) and lacks the V beta gene segment used by the T cell clone. Expression of the tg beta chain on all thymocytes and peripheral lymph node T cells led to a more efficient anti-CII immune response, but did not confer CIA susceptibility to SWR/J mice. Nevertheless, this tg beta chain enhanced predisposition to CIA as (DBA/1 x SWR) F1 beta tg mice were more susceptible than normal F1 littermates. Our results demonstrate that the expression of the tg beta chain contributes to CIA susceptibility, but by itself it is not sufficient to overcome CIA resistance in the SWR/J strain.
摘要
构建了表达源自抗II型胶原（CII）致关节炎T细胞克隆的TCRβ链的SWR/J转基因（tg）小鼠。选择SWR/J品系是因为它对胶原诱导的关节炎（CIA）具有抗性，并且缺乏该T细胞克隆所使用的Vβ基因片段。tgβ链在所有胸腺细胞和外周淋巴结T细胞上的表达导致了更有效的抗CII免疫反应，但并未使SWR/J小鼠对CIA易感。然而，由于（DBA/1×SWR）F1βtg小鼠比正常F1同窝小鼠更易感，这种tgβ链增强了对CIA的易感性。我们的结果表明，tgβ链的表达有助于CIA易感性，但仅凭其自身不足以克服SWR/J品系对CIA的抗性。
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