意大利拉齐奥地区透析单位的乙型肝炎病毒感染控制

Control of hepatitis B virus infection in dialysis units in Latium, Italy.

作者信息

Franco E, Olivadese A, Valeri M, Albertoni F, Petrosillo N

机构信息

Department of Public Health, 2nd University, Rome, Italy.

出版信息

Nephron. 1992;61(3):329-30. doi: 10.1159/000186927.

DOI:10.1159/000186927

PMID:1386906

Abstract

The prevalence of hepatitis B virus (HBV) markers was assessed in 1,841/2,178 (84.5%) dialysis patients (DP) cared for in 38/47 dialysis units (80.9%) in Latium. Among DP, 205 (11.1%) were HBsAg positive: 13.8% of males and 7.1% of females (p less than 0.001); the prevalence increased with the length of time on dialysis (p for trend less than 0.001). No differences in HBV (HBsAg and/or anti-HBc) distribution were seen related to age and sex. Of 664/1,539 vaccinated DP, 150 (22.6%) were anti-HBc positive and 239 (36.0%) positive for anti-HBs alone. Of 875/1,539 nonvaccinated patients, 146 (16.7%) had no HBV marker. Vaccination against HBV did not influence the diffusion of HBV in our dialysis units and must be coupled with the implementation of long-standing infection control strategies.

摘要

在拉齐奥地区47个透析单位中的38个（80.9%）接受治疗的2178名透析患者（DP）中的1841名（84.5%）中评估了乙肝病毒（HBV）标志物的流行情况。在透析患者中，205名（11.1%）HBsAg呈阳性：男性为13.8%，女性为7.1%（p<0.001）；患病率随透析时间的延长而增加（趋势p<0.001）。未观察到HBV（HBsAg和/或抗-HBc）分布在年龄和性别方面存在差异。在1539名接种疫苗的透析患者中，664名中有150名（22.6%）抗-HBc呈阳性，239名（36.0%）仅抗-HBs呈阳性。在1539名未接种疫苗的患者中，875名中有146名（16.7%）没有HBV标志物。乙肝疫苗接种并未影响乙肝病毒在我们透析单位中的传播，必须结合长期感染控制策略的实施。