Farkas-Bargeton E, Diebler M F, Arsénio-Nunes M L, Wehrlé R, Rosenberg B
J Neurol Sci. 1977 Mar;31(2):245-59. doi: 10.1016/0022-510x(77)90110-1.
Histochemical studies of muscle specimens from human fetuses showed: (a) a uniform fiber type population having the properties of Type IIC fibres up to 19 weeks of development; (b) a progressive appearance of Type I fibres after that age; (c) a decrease in number of Type IIC fibres during the last 3 months of pregnancy, accompanied by the appearance of Type IIB and Type IIA fibres; (d) the presence after the myotube stage of fibers with a light peripheral halo in sections stained for mitochondrial dehydrogenases. Electron-microscopic examination of the muscle fibres confirmed the existence of a peripheral halo devoid of myofibrils and mitochondria and showed: (a) scarcity of myofibrils in comparison with mature muscle fibres and (b) irregularity in shape of the myofibrils. In addition, quantitative studies demonstrated an important variation of the fibre diameters up to 21 weeks and the increase of the mean diameter after this age. It is suggested that the persistence after birth of some features of immaturity identical to those described in this work may be considered as a pathological finding.
(a) 在发育至19周时，存在具有IIC型纤维特性的单一纤维类型群体；(b) 该年龄之后，I型纤维逐渐出现；(c) 在妊娠最后3个月期间，IIC型纤维数量减少，同时出现IIB型和IIA型纤维；(d) 在肌管阶段之后，在用线粒体脱氢酶染色的切片中，存在具有浅色外周晕的纤维。对肌肉纤维的电子显微镜检查证实存在无肌原纤维和线粒体的外周晕，并显示：(a) 与成熟肌肉纤维相比，肌原纤维稀少；(b) 肌原纤维形状不规则。此外，定量研究表明，直至21周纤维直径存在重要变化，该年龄之后平均直径增加。有人提出，出生后持续存在一些与本研究中描述的不成熟特征相同的情况可被视为一种病理表现。
