克拉霉素与红霉素对1型人类免疫缺陷病毒感染个体的J774细胞和肺泡巨噬细胞中鸟分枝杆菌复合群菌株的细胞内活性比较。
Comparison of the intracellular activities of clarithromycin and erythromycin against Mycobacterium avium complex strains in J774 cells and in alveolar macrophages from human immunodeficiency virus type 1-infected individuals.
作者信息
Yajko D M, Nassos P S, Sanders C A, Gonzalez P C, Hadley W K
机构信息
Department of Laboratory Medicine, University of California, San Francisco General Hospital 94110.
出版信息
Antimicrob Agents Chemother. 1992 May;36(5):1163-5. doi: 10.1128/AAC.36.5.1163.
Abstract
The intracellular activities of clarithromycin and erythromycin, alone and in combination with other antimicrobial agents, were tested against Mycobacterium avium complex (MAC) strains inside mouse J774 cells and inside alveolar macrophages obtained from human immunodeficiency type 1-infected individuals. Clarithromycin alone had greater intracellular activity than erythromycin alone, and drug combinations that included clarithromycin were usually more active than combinations that included erythromycin.
摘要
对克拉霉素和红霉素单独以及与其他抗菌药物联合使用时的细胞内活性进行了测试，受试对象为小鼠J774细胞内以及从1型人类免疫缺陷病毒感染个体获取的肺泡巨噬细胞内的鸟分枝杆菌复合群（MAC）菌株。单独使用时，克拉霉素的细胞内活性比红霉素更强，且包含克拉霉素的药物组合通常比包含红霉素的组合活性更高。
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