对克拉霉素和阿奇霉素耐药的鸟分枝杆菌菌株
Mycobacterium avium strains resistant to clarithromycin and azithromycin.
作者信息
Heifets L, Mor N, Vanderkolk J
机构信息
National Jewish Center for Immunology, and Respiratory Medicine, University of Colorado Health Sciences Center, Denver.
出版信息
Antimicrob Agents Chemother. 1993 Nov;37(11):2364-70. doi: 10.1128/AAC.37.11.2364.
Abstract
Mycobacterium avium strains susceptible to clarithromycin and azithromycin contain mutants resistant to these macrolides with a frequency of 1.1 x 10(-10) to 1.2 x 10(-6). Cross-resistance between clarithromycin and azithromycin was demonstrated with mutants selected in the laboratory as well as with resistant strains isolated from patients. The susceptibility-resistance patterns of the macrolide-resistant strains with drugs other than macrolides were the same as those of the original susceptible strains. The emergence of clarithromycin resistance in patients was a result of multiplication of the preexisting resistant mutants that survived the elimination of bacteria during the initial period of treatment and was an exclusive cause of the relapse of bacteremia.
摘要
对克拉霉素和阿奇霉素敏感的鸟分枝杆菌菌株含有对这些大环内酯类药物耐药的突变体，其频率为1.1×10⁻¹⁰至1.2×10⁻⁶。在实验室中选择的突变体以及从患者中分离出的耐药菌株均显示出克拉霉素和阿奇霉素之间的交叉耐药性。大环内酯类耐药菌株对大环内酯类以外药物的药敏模式与原始敏感菌株相同。患者中克拉霉素耐药性的出现是由于治疗初期细菌被清除过程中存活下来的预先存在的耐药突变体增殖所致，并且是菌血症复发的唯一原因。
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Thorax. 1950 Jun;5(2):144-61. doi: 10.1136/thx.5.2.144.
2
MICs and MBCs of clarithromycin against Mycobacterium avium within human macrophages.克拉霉素对人巨噬细胞内鸟分枝杆菌的最低抑菌浓度（MICs）和最低杀菌浓度（MBCs）
Antimicrob Agents Chemother. 1993 Jan;37(1):111-4. doi: 10.1128/AAC.37.1.111.
3
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4
In vitro activities of several new macrolide antibiotics against Mycobacterium avium complex.几种新型大环内酯类抗生素对鸟分枝杆菌复合体的体外活性
Antimicrob Agents Chemother. 1989 Sep;33(9):1614-6. doi: 10.1128/AAC.33.9.1614.
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7
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8
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